The NCT/UCC Directorate Dresden runs the NCT and is responsible for the development and implementation of the strategic and operational measures. It consists of directors of oncological departments of the University Hospital Carl Gustav Carus Dresden, institute directors of the Helmholtz-Zentrum Dresden-Rossendorf, and professors of the Carl Gustav Carus Faculty of Medicine at the TU Dresden. The German Cancer Consortium (DKTK) is also part of the NCT/UCC Directorate Dresden.
The Managing Directorate consists of four managing directors.