MNP Int R

The constantly growing diversity of CNS tumour types in childhood and adolescence is reflected in extremely different disease progressions, and the rarity of individual tumour types and their varying appearances often make diagnosis difficult. However, the correct classification of CNS tumours is of paramount importance for the selection of the optimal treatment strategy for each patient. In order to increase diagnostic accuracy and thereby support accurate classification, MNP Int R will investigate CNS tumours at the time of initial diagnosis using molecular genetic analysis methods. Primary objectives Establishment of comprehensive molecular diagnostics Establishment of an international register for molecular diagnostic data Integration of neuropathological reference diagnosis, radiological reference findings and molecular genetic results in a multi-layered diagnosis Further development of DNA methylation-based CNS tumour classification Correlation of molecular diagnostic parameters with clinical disease progression Analysing the collected data Provision of data and assistance in the interpretation of molecular genetic information for clinicians, patients and their parents, as well as scientists

{ "short_title": "MNP Int R", "data_mode": "900", "data_mode_number": "000002467", "official_title": "Internationales Molekulare Neuropathologie Register", "accrual_state": "running", "therapeutic_value": null, "therapieansatz_value": null, "therapieintervention_value": null, "therapielinie_value": null, "ctgov_number": null, "eudract_number": null, "general_contact_email": "Kik-dokuteam-hs65@ukdd.de", "general_contact_phone": "+49 351-4585035", "hauptpruefer_dd_name": "Dr. med. Claudia Zinke", "description_laie_de": "Die stetig wachsende Vielfalt von Tumorarten des ZNS im Kindes- und Jugendalter spiegelt sich in extrem unterschiedlichen Krankheitsverl\u00e4ufen wieder, und die Seltenheit einzelner Tumorarten sowie deren variierende Erscheinungsbilder erschweren die Diagnosestellung h\u00e4ufig. Die korrekte Klassifizierung von Tumoren des ZNS ist jedoch von au\u00dfergew\u00f6hnlicher Bedeutung f\u00fcr die Auswahl der optimalen Therapiestrategie f\u00fcr jeden Patienten. Um die diagnostische Genauigkeit zu erh\u00f6hen und dadurch die genaue Klassifizierung zu unterst\u00fctzen, werden im Rahmen von MNP Int R Tumore des ZNS zum Zeitpunkt der Erstdiagnose mittels molekulargenetischer Analyseverfahren untersucht.\r\n\r\nPrim\u00e4re Ziele\r\nEtablierung einer fl\u00e4chendeckenden Molekulardiagnostik\r\nAufbau eines internationalen Registers f\u00fcr molekulardiagnostische Daten\r\nIntegration neuropathologischer Referenzdiagnose, radiologischer Referenzbefunde und molekulargenetischer Ergebnisse in einer mehrschichtigen Diagnose\r\nWeiterentwicklung der DNA Methylierungs-basierten ZNS Tumorklassifikation\r\nKorrelation molekulardiagnostischer Parameter mit klinischen Krankheitsverl\u00e4ufen\r\nAuswertung der gesammelten Daten\r\nBereitstellung der Daten und Hilfestellung bei der Interpretation molekulargenetischer Informationen f\u00fcr Klinikern, Patienten bzw. deren Eltern, sowie Wissenschaftler", "description_laie_en": null, "description_expert_de": null, "description_expert_en": "The constantly growing diversity of CNS tumour types in childhood and adolescence is reflected in extremely different disease progressions, and the rarity of individual tumour types and their varying appearances often make diagnosis difficult. However, the correct classification of CNS tumours is of paramount importance for the selection of the optimal treatment strategy for each patient. In order to increase diagnostic accuracy and thereby support accurate classification, MNP Int R will investigate CNS tumours at the time of initial diagnosis using molecular genetic analysis methods.\r\n\r\nPrimary objectives\r\nEstablishment of comprehensive molecular diagnostics\r\nEstablishment of an international register for molecular diagnostic data\r\nIntegration of neuropathological reference diagnosis, radiological reference findings and molecular genetic results in a multi-layered diagnosis\r\nFurther development of DNA methylation-based CNS tumour classification\r\nCorrelation of molecular diagnostic parameters with clinical disease progression\r\nAnalysing the collected data\r\nProvision of data and assistance in the interpretation of molecular genetic information for clinicians, patients and their parents, as well as scientists", "rechtsgrundlage_value": "BO", "phase_amg_value": null, "main_cat_id": 14, "sub_cat_id": 62 }

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