Description for experts
Open distal pancreatectomy is the gold standard in the surgical treatment of pancreatic body and tail disease. The open abdominal approach could lead to increased postoperative morbidity due to the greater surgical trauma compared with minimally invasive distal pancreatectomy, which affects both the patient and the healthcare system. A systematic review demonstrated reduced postoperative morbidity after laparoscopic versus open abdominal approaches across the field of abdominal surgery.
The minimally invasive approach, with its less invasiveness, promises to reduce postoperative pain and subsequently improve patient mobilization and reduce respiratory complications, leading to faster recovery and shorter hospital stays. Therefore, in the presence of the same postoperative morbidity, the minimally invasive approach should be offered to patients as the first choice.
Description for laymen
JSON Data
{
"short_title": "DISPACT-2",
"data_mode": "900",
"data_mode_number": "000002417",
"official_title": "Distal Pancreatectomy - A randomised controlled trial to \r\ncompare minimal-invasive distal pancreatectomy to open \r\nresection (DISPACT-2 Trial)",
"accrual_state": "running",
"therapeutic_value": "therapeutic",
"therapieansatz_value": "kurativ",
"therapieintervention_value": "not_applicable",
"therapielinie_value": "not_applicable",
"ctgov_number": null,
"eudract_number": null,
"general_contact_email": "studienzentrum-vtg@ukdd.de",
"general_contact_phone": null,
"hauptpruefer_dd_name": "Prof. Dr. med. Marius Distler",
"description_laie_de": "Der Behandlungserfolg einer Operation ist nicht nur abh\u00e4ngig von der Erkrankung, sondern auch vom Schaden des chirurgischen Zugangs. Die minimal invasive Operation vermindert postoperative Schmerzen und f\u00fchrt zu verbesserter Mobilit\u00e4t, weniger pulmonalen Infekten und schnellerer Erholung und einer besseren Lebensqualit\u00e4t.\r\nDie DISPACT 2-Studie untersucht Unterschiede zwischen offener und minimal invasiver distaler Pankreasresektion bez\u00fcglich postoperativer Komplikationen, weiterer klinischer und onkologischer Wirksamkeit, Sicherheit, Lebensqualit\u00e4t und Kosten. Zudem werden patientenrelevante Ergebnisse und onkologische Sicherheit untersucht. Im Falle von gleich vielen postoperativen Komplikationen und gegebener onkologischer Sicherheit und bei gleichzeitig verbesserter Lebensqualit\u00e4t sollte die minimal invasive Resektion den Patienten als erste Wahl angeboten werden.",
"description_laie_en": null,
"description_expert_de": null,
"description_expert_en": "Open distal pancreatectomy is the gold standard in the surgical treatment of pancreatic body and tail disease. The open abdominal approach could lead to increased postoperative morbidity due to the greater surgical trauma compared with minimally invasive distal pancreatectomy, which affects both the patient and the healthcare system. A systematic review demonstrated reduced postoperative morbidity after laparoscopic versus open abdominal approaches across the field of abdominal surgery.\r\nThe minimally invasive approach, with its less invasiveness, promises to reduce postoperative pain and subsequently improve patient mobilization and reduce respiratory complications, leading to faster recovery and shorter hospital stays. Therefore, in the presence of the same postoperative morbidity, the minimally invasive approach should be offered to patients as the first choice.",
"rechtsgrundlage_value": "BO",
"phase_amg_value": null,
"main_cat_id": 2,
"sub_cat_id": 4
}
