IndiTRec

The aim of this scientific investigation is to find biological factors (biomarkers) that allow the efficacy of radiochemotherapy and the course of the disease to be predicted. This means that the tumour cells are taken in cell culture and then exposed to the same treatment that you are receiving. In the end, the response of your tumour in the body will be compared with that of the tumour in cell culture. In addition, components of the tumour such as proteins, the genetic material (genes, sections on the DNA) and the carriers of genetic information (RNA molecules) are examined using laboratory methods in order to be able to determine more reliably in future whether a tumour will reappear or not.

{ "short_title": "IndiTRec", "data_mode": "900", "data_mode_number": "000001345", "official_title": "Individualisierung der Therapie des Rektumkarzinoms durch Pr\u00e4diktion des Therapieansprechens auf neoadjuvante Radiochemotherapie mittels Organoidkulturen\r\n\r\nIndiTRec - Individualized Treatment of Rectal Cancer", "accrual_state": "running", "therapeutic_value": "nonTherapeutic", "therapieansatz_value": "not_applicable", "therapieintervention_value": "not_applicable", "therapielinie_value": "not_applicable", "ctgov_number": null, "eudract_number": null, "general_contact_email": "studienzentrum-vtg@ukdd.de", "general_contact_phone": null, "hauptpruefer_dd_name": "Prof. Dr. med. Daniel Stange", "description_laie_de": "Ziel dieser wissenschaftlichen Untersuchung ist es, biologische Faktoren (Biomarker) zu finden, die eine Vorhersage der Wirksamkeit der Radiochemotherapie und des Krankheitsverlaufs erm\u00f6glichen. Das hei\u00dft, dass die Tumorzellen in Zellkultur genommen werden und dann der gleichen Behandlung ausgesetzt werden, die Sie auch erhalten. Am Ende soll das Ansprechen Ihres Tumors im K\u00f6rper mit dem des Tumors in Zellkultur verglichen werden. Daneben werden Bestandteile des Tumors wie Eiwei\u00dfe (Proteine), die Erbsubstanz (Gene, Abschnitte auf der DNA) und die \u00dcbertr\u00e4ger der genetischen Informationen (RNA-Molek\u00fcle) mit Labormethoden untersucht, um zuk\u00fcnftig verl\u00e4sslicher bestimmen zu k\u00f6nnen, ob ein Tumor wieder auftritt oder nicht.", "description_laie_en": null, "description_expert_de": null, "description_expert_en": "The aim of this scientific investigation is to find biological factors (biomarkers) that allow the efficacy of radiochemotherapy and the course of the disease to be predicted. This means that the tumour cells are taken in cell culture and then exposed to the same treatment that you are receiving. In the end, the response of your tumour in the body will be compared with that of the tumour in cell culture. In addition, components of the tumour such as proteins, the genetic material (genes, sections on the DNA) and the carriers of genetic information (RNA molecules) are examined using laboratory methods in order to be able to determine more reliably in future whether a tumour will reappear or not.", "rechtsgrundlage_value": "BO", "phase_amg_value": null, "main_cat_id": 2, "sub_cat_id": 6 }